MH Guide CAS
Variant annotation and
reporting solution

Streamlined genomic data workflow

MH Guide CAS rapidly annotates results from NGS tumor profiling panels and matches them to curated therapy associations, biomarkers, and recruiting clinical trials. All information can be included and archived in customizable summary reports. MH Guide CAS helps research laboratories to accelerate cancer discoveries and is powered by Molecular Health’s Knowledge Base Dataome.

Simple, efficient reporting

Besides showcasing in-depth information, MH Guide CAS provides research laboratories with a concise summary report, including relevant biomarkers, pathogenic variants, and published treatment associations.

Curated, quality-assured data

Molecular Health’s expert biomedical curation team evaluates and summarizes published study results and drug approval data and applies strict quality-controlled standards. When research laboratories utilize our software, they can access reliable, high-quality insights.

Accessible, worldwide knowledge

Combining NGS data with global data from Molecular Health’s powerful and continuously updated knowledge base Dataome, MH Guide CAS provides highly comprehensive annotations and curated treatment associations from publications.

Concise, transparent information 

Variant information in MH Guide CAS is concise and transparent. All information comes with references to data sources and publications, variants are classified based on acknowledged standards and evidence categories, and published variant information is concisely summarized by expert-curators.

ISO 13485

Molecular Health is certified according to EN ISO 13485:2016. Our certified quality management system includes standard operating procedures (SOPs) for the operation of productive IT systems, IT business continuity.


MH Guide CAS meets the requirements of the General Data Protection Regulation (GDPR) in Europe, the Genetic Diagnostics Act (GenDG) in Germany and the Health Insurance Portability and Accountability Act (HIPAA) in the USA.

Data Security

MH employs advanced encryption standards (SSL/TLS, AES-256) to safeguard patient data and stores it with controlled access authorization. Additionally, MH utilizes data centers certified according to international security standards, including Trusted Site Infrastructure (TSI) and ISO 27001:2013.

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